Cristiano Ronaldo took his tally for the La Liga season to a phenomenal 13 goals in six appearances with his third treble of the campaign as Real Madrid romped to a 5-0 win at home to Athletic Bilbao on Sunday.
Here are five talking points from the weekend in La Liga:
Cristiano Ronaldo scored his 400th goal for Real Madrid as Zinedine Zidane's side closed in on a first La Liga title since 2012, easing to a 4-1 win over Sevilla on Sunday while Neymar hit a hat-trick for Barcelona, who thrashed Las Palmas 4-1.
Zinedine Zidane got off to a flying start as Real Madrid coach when Gareth Bale hit a hat-trick in a 5-0 win over Deportivo La Coruna on Saturday after a Lionel Messi treble had fired Barcelona to the top of La Liga.
Europa League favourites Manchester United secured a 1-1 draw on a threadbare pitch at Rostov, while Olympique Lyonnais beat AS Roma 4-2 helped by a fine individual goal from Nabil Fekir in their last 16, first leg ties on Thursday.
Cristiano Ronaldo continued his prolific start to the season with four goals, including two penalties, as Real Madrid came from behind to beat Elche 5-1 in La Liga on Tuesday.
Tottenham Hotspur's Europa League hopes were crushed by mid-table Belgian side Gent, who booked their spot in the last 16 with a 2-2 draw at Wembley on Thursday as the hosts paid the penalty for Dele Alli's first-half red card.
Alexis Sanchez hit a hat-trick as Barcelona swept aside Elche 4-0 to return to the top of La Liga on goal difference ahead of Atletico Madrid on Sunday.
Images from Saturday's La Liga action.
Barcelona's poor run away to Real Sociedad continued when the champions were held to a 1-1 draw at Anoeta on Sunday and slipped six points behind La Liga leaders Real Madrid before next week's 'Clasico' against their arch rivals.
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Barcelona's preparations for next season were thrown off course on Friday when the Spanish champions unexpectedly announced coach Tito Vilanova was stepping down due to ill health.
Barcelona's attacking trio of Lionel Messi, Luis Suarez and Neymar were all on target as the champions roared back into life in La Liga with a dominant 5-1 victory at promoted Leganes on Saturday. Messi sidefooted in a simple cross from Suarez to strike the opening goal after 15 minutes and returned the favour for the Uruguayan to nudge in the second in the 31st.
Cristiano Ronaldo struck the quickest hat-trick of his career on his way to netting five goals in Real Madrid's 9-1 drubbing of second-from-bottom Granada on Sunday which took Real to within a point of La Liga leaders Barcelona.
Images from La Liga matches played on Monday.
Sweden missed the influence of captain Zlatan Ibrahimovic, who was resting a sore calf muscle, as they struggled to create chances in a dull 0-0 draw with Slovenia in their penultimate Euro 2016 warm-up in Malmo on Monday.
Chelsea manager Jose Mourinho said striker Diego Costa will start against Liverpool in the Premier League at Anfield on Saturday despite being left out of the Spain squad for this month's international matches because of persistent injuries.
Barcelona dropped their first points of the La Liga season as their star-studded forward line misfired in a 0-0 draw away to Malaga on Wednesday.
Lopetegui blends youth and experience in Spain World Cup squad
Real Madrid's La Liga title bid took a dent after Zinedine Zidane's leaders were held to a 2-2 draw at home to Celta Vigo on Sunday, denied all three points by a late strike from Santi Mina. Lazio mounted a superb second-half comeback at the Olympic Stadium to beat Inter Milan 2-1 and move above Antonio Conte's side into second place in Serie A on Sunday.
Second division Mirandes caused an upset by knocking Deportivo La Coruna out of the King's Cup on Tuesday and Sevilla joined them in the quarter-finals after making light work of city rivals Real Betis.
Champions Barcelona suffered their second defeat in three matches in La Liga on Saturday, with Michael Krohn-Dehli scoring and setting up another goal in a 2-1 victory for Sevilla.
Messi's contract expires at the end of June and there has been no announcement on an extension.
Real Madrid and Atletico each slipped 10 points behind La Liga leaders Barcelona after an intense Madrid derby finished goalless and the Catalans picked up an 11th victory in 12 games by winning 3-0 at Leganes.
Real Madrid became La Liga champions for the first time since 2012 on Sunday with a 2-0 win at Malaga, denying arch-rivals Barcelona three consecutive league titles.
Espanyol's Felipe Caicedo came off the bench and netted two late goals to secure a 2-0 win at home to 10-man Valencia on Tuesday that sent the Barcelona-based club through to the King's Cup quarter-finals 3-2 on aggregate.
La Liga leaders Real Madrid returned to winning ways after two defeats, making light of playing most of the second half with 10 men to triumph 3-0 at home to mid-table Espanyol on Saturday.
Real Madrid secured a club record 16th straight victory when Karim Benzema and Gareth Bale struck in a laboured 2-1 win at Malaga on Saturday that put them five points clear of second-placed Barcelona in La Liga.
While Gareth Bale is fully expected to regain his place in the Real Madrid side when he returns from injury, team mate Isco is making the most of his chance to prove his worth on the pitch.
News of all that's transpired on and off the football field
Atletico Madrid suffered a first defeat in 13 games in all competitions as they lost 1-0 at home to Villarreal on Tuesday after a late strike from substitute Roberto Soriano.
Lionel Messi scored twice as La Liga champions Barcelona saw off a persistent Valencia side, who had Eliaquim Mangala sent off in the first half, to win 4-2 on Sunday and stay on the heels of leaders Real Madrid.
Barca finished the season second in the standings on 82 points, four behind champions Real Madrid who visit Leganes later on Sunday. Alaves are 16th on 39.
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Real Madrid took full advantage of Barcelona's shock defeat at Real Valladolid with a 3-0 home win over 10-man Levante on Sunday that put Carlo Ancelotti's in-form side three points clear at the top of La Liga.
Real Madrid lifted the FIFA Club World Cup for a record fourth time on Saturday after thrashing local side Al Ain 4-1 in the final in Abu Dhabi with the help of impressive distance strikes in either half from midfielders Luka Modric and Marcos Llorente.
Atletico Madrid's Brazil-born forward Diego Costa has signed a formal letter stating his wish to play for adopted country Spain, ending a tug-of-war between the two powerhouses over the in-form 25-year-old.
Promoted Alaves dealt champions Barcelona a shock 2-1 defeat at the Nou Camp on Saturday while Cristiano Ronaldo returned from injury to help Real Madrid thrash Osasuna 5-2 and go two points clear at the top of La Liga. With Lionel Messi, Luis Suarez and Andres Iniesta on the bench, Barcelona went behind to the visitors in the 39th minute before Frenchman Jeremy Mathieu equalised in the 46th. Ibai Gomez then scored the winner in the 64th.
Lionel Messi announced on Friday that he wants to return to play for the national team, reversing his decision to retire earlier this year. Messi said in June that he would not play for Argentina again after the team lost to Chile in the final of the Copa America.
Real Madrid closed to within two points of La Liga leaders Barcelona after demolishing nine-man Rayo Vallecano 10-2 while Atletico Madrid missed a chance to seize top spot outright by losing 1-0 at Malaga.
Cristiano Ronaldo finally became the highest scorer in Real Madrid's history while Bayern Munich set a record for the greatest number of successive wins at the start of a season in the Bundesliga this weekend.
Lionel Messi, Luis Suarez and Neymar were being touted as the best strike force in soccer history a month ago as they spearheaded Barcelona's record unbeaten run but the tiring trio are now taking the blame as the club's season unravels.
